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Cardiovascular

Trigeminal Neuralgia


Causes

  • Vascular compression (artery/vein, most common)

  • Tumour/mass effect

  • Multiple sclerosis (demyelination at nerve root)

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History

  • Severe, sharp, stabbing pain in V2/V3 distribution

  • Paroxysmal attacks (seconds to minutes) with refractory periods

  • Triggered by cold/hot drinks, brushing teeth, wind, shaving, light touch

  • Can mimic migraine (sudden intense pain)

  • More common in older adults, slight female predominance

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Examination

  • Trigger zones (nasolabial fold, upper cheek)

  • Tic douloureux (brief facial twitching from pain)

  • Allodynia/hyperalgesia in affected area

  • Neurological exam otherwise normal

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Investigations

  • MRI brain with trigeminal nerve focus (rule out MS, tumours)

  • Neurophysiological studies (if atypical presentation)

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Management

  • Educate on nerve irritation, trigger avoidance

  • Non-urgent neurology referral

  • First-line: Carbamazepine (start 100 mg BD, titrate as needed)

  • Second-line: Oxcarbazepine (if intolerant to carbamazepine)

  • Monitor for side effects: Depression, hyponatraemia, dizziness

  • Baclofen (adjunct or alternative in refractory cases)

  • Surgical decompression (if severe, persistent, or confirmed neurovascular compression)

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