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Cardiovascular

Delirium


Confusion Assessment Method (CAM)

Requires 1 + 2 and either 3 or 4:

  1. Acute onset, fluctuating course (changes in mental status, attention deficits)

  2. Inattention (key criterion)

  3. Disorganised thinking

  4. Altered consciousness (hyperalert or drowsy)

  5. Alternative rapid tool: 4AT (validated for quick screening)

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Differentials

  • Medications/withdrawal (alcohol, illicit drugs)

  • Sleep deprivation, pain, abuse

  • B12 deficiency

  • Infections: UTI, pneumonia

  • Constipation, urinary retention

  • Dementia (including Lewy body dementia)

  • Neurological: Stroke, brain tumour

  • Organ failure: Respiratory, cardiac, renal

  • Electrolytes: Hyponatraemia, hypoglycaemia

  • MI, arrhythmia

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Prevention (also risk factors)

  • Quiet environment, minimal stimulation

  • Familiar objects, clocks, calendars

  • Regular sleep schedule, optimise sleep hygiene

  • Correct vision/hearing impairments

  • Adequate pain relief, avoid deliriogenic meds

  • Proper lighting (day-night cycle support)

  • Encourage familiar person’s presence

  • Hydration, nutrition

  • Avoid restraints unless essential

  • Structured reorientation, cognitive stimulation

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Management


Non-Pharmacological

  • Low-stimulus environment, minimise noise

  • Frequent reorientation, clear/calm communication

  • Approach from the front, maintain eye contact

  • Encourage familiar person's presence, ensure personal belongings

  • Secure sharp objects, one-to-one nursing if needed

  • Inform family of status changes

  • Review medications & fluid balance


Pharmacological (if severe behavioural disturbance, hallucinations, or delusions)

  • First-line: Risperidone 0.25 mg BD (max 1 mg BD)

  • Second-line: Olanzapine 2.5 mg OD (max 10 mg OD)

  • Dementia/Lewy body dementia: Low-dose quetiapine

  • Use lowest effective dose, shortest duration, monitor vitals


For Anxiety/Agitation

  • Oxazepam 7.5 mg TDS PRN


For Acute Behavioural Changes (Stat Dose)

  • First-line: Haloperidol or risperidone 0.5 mg PO (repeat in 30 min if needed)

  • If oral not feasible: Haloperidol 0.5 mg IM

  • Monitor & adjust therapy based on response & EPSE risk

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