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Cardiovascular

Spirometry


Withholding Bronchodilators

  • SABA: 4 hrs

  • SAMA: 12 hrs

  • ICS/LABA (bd): 24 hrs

  • LAMA/LABA (od): 36 hrs

  • Combo: Follow longer time

  • Ensures accurate baseline for obstruction assessment

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Procedure

  1. Pre-test: Salbutamol 100 mcg x4 (via spacer), 30 secs apart, wait 10 mins

  2. Perform pre- and post-bronchodilator tests

  3. At least 3 acceptable blows, <5% variability (best 2 efforts)

  4. Avoid poor technique (coughing, submaximal effort, abrupt stop)

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Ventilatory Defects

  • Obstructive:

    • FEV₁/FVC <0.7 or LLN (concave loop)

    • E.g. Asthma, COPD, overlap

  • Restrictive:

    • FVC <0.8 or LLN; FEV₁/FVC normal/increased

    • E.g. Interstitial lung disease, obesity

  • Mixed:

    • Low FEV₁/FVC + Low FVC → Needs lung volume testing

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Reversibility

  • Adults: ≥12% + 200 mL improvement in FEV₁ or FVC post-bronchodilator

  • Children: ≥12% alone sufficient

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Severity (Post-Bronchodilator FEV₁)

  • Mild: >80%

  • Moderate: 50–80%

  • Severe: 30–50%

  • Very Severe: <30%

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Key Notes

  • COPD: Post-FEV₁/FVC <0.7, FEV₁ <80% predicted confirms

  • Asthma: ≥12% FEV₁ improvement supports diagnosis

  • Pre vs. post helps differentiate asthma vs. COPD

  • Repeat spirometry if unclear or to monitor treatment response

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