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Cardiovascular

Smoking Cessation



When to Start Pharmacotherapy

  • Indications for pharmacotherapy (any of the following):

    • Smoking within 30 min of waking (best indicator)

    • 10 cigarettes/day

    • Withdrawal symptoms during prior quit attempts

    • Comorbid mental health conditions


Questions to Assess Willingness to Quit

  • Have you considered quitting?

  • Are you ready to quit now?

  • What were your experiences with previous quit attempts?

  • What barriers prevent you from quitting?

  • What are your triggers or high-risk situations?


Non-Pharmacological Strategies

  1. Plan Quit Date: Agree on a specific day to quit

  2. Smoking Cessation Support: Refer to a program (e.g., Quitline)

  3. Craving Management:

    • 4 D’s: Delay, Distract, Deep breathing, Drink water

    • Physical activity to reduce cravings

  4. Motivational Interviewing: Explore and resolve ambivalence

  5. Follow-Up: Arrange review within 1 week

  6. Education: Provide written materials on quitting strategies


Smoking Cessation: Varenicline


Mechanism of Action: Nicotine partial agonist


Dosing Schedule

  • Day 1–3: 0.5 mg OD

  • Day 4–7: 0.5 mg BD

  • Week 2–12: 1 mg BD

  • Set quit date after 1st week of therapy


Adverse Effects

  • Nausea (most common)

  • Abnormal dreams

  • Mood changes: depression, irritability, suicidality (monitor closely in psychiatric history)

  • Caution: History of seizures or cardiovascular disease


Contraindications

  • Severe renal impairment

  • Pregnancy, breastfeeding, adolescence

  • Concurrent use with specific medications (check interactions)


Precautions

  • Monitor:

    • Psychiatric illness (close supervision)

    • Cardiovascular events (e.g., angina)

    • Hepatic impairment (assess LFTs if indicated)


Counselling

  • Explain common side effects (e.g., nausea, abnormal dreams)

  • Adherence to dosing improves outcomes

  • Cravings may increase after cessation; support is crucial

  • Combine with nicotine replacement therapy (if suitable) for better success

  • PBS subsidy requires enrolment in a cessation program

  • Regular follow-up to assess progress, provide behavioural support


Outcome

  • Doubles chances of long-term cessation with proper adherence and support.

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