
Smoking Cessation
When to Start Pharmacotherapy
Indications for pharmacotherapy (any of the following):
Smoking within 30 min of waking (best indicator)
10 cigarettes/day
Withdrawal symptoms during prior quit attempts
Comorbid mental health conditions
Questions to Assess Willingness to Quit
Have you considered quitting?
Are you ready to quit now?
What were your experiences with previous quit attempts?
What barriers prevent you from quitting?
What are your triggers or high-risk situations?
Non-Pharmacological Strategies
Plan Quit Date: Agree on a specific day to quit
Smoking Cessation Support: Refer to a program (e.g., Quitline)
Craving Management:
4 D’s: Delay, Distract, Deep breathing, Drink water
Physical activity to reduce cravings
Motivational Interviewing: Explore and resolve ambivalence
Follow-Up: Arrange review within 1 week
Education: Provide written materials on quitting strategies
Smoking Cessation: Varenicline
Mechanism of Action: Nicotine partial agonist
Dosing Schedule
Day 1–3: 0.5 mg OD
Day 4–7: 0.5 mg BD
Week 2–12: 1 mg BD
Set quit date after 1st week of therapy
Adverse Effects
Nausea (most common)
Abnormal dreams
Mood changes: depression, irritability, suicidality (monitor closely in psychiatric history)
Caution: History of seizures or cardiovascular disease
Contraindications
Severe renal impairment
Pregnancy, breastfeeding, adolescence
Concurrent use with specific medications (check interactions)
Precautions
Monitor:
Psychiatric illness (close supervision)
Cardiovascular events (e.g., angina)
Hepatic impairment (assess LFTs if indicated)
Counselling
Explain common side effects (e.g., nausea, abnormal dreams)
Adherence to dosing improves outcomes
Cravings may increase after cessation; support is crucial
Combine with nicotine replacement therapy (if suitable) for better success
PBS subsidy requires enrolment in a cessation program
Regular follow-up to assess progress, provide behavioural support
Outcome
Doubles chances of long-term cessation with proper adherence and support.
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