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Cardiovascular

Shingles & Postherpetic Neuralgia (PHN)

Shingles


Treatment

  • Prodrome: Burning pain, headache, fever, lymphadenopathy

  • Antivirals (if within 72 hrs of rash onset): Valaciclovir 1 g TDS x 7 days

    • Start anytime if immunocompromised or ophthalmic involvement

  • Consider Prednisolone 50 mg OD x 7 days (severe cases)

  • Symptomatic relief: Ice packs, paracetamol

  • Early antiviral therapy ↓ PHN risk

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Postherpetic Neuralgia (PHN)

  • Persistent pain >3 months post-infection (rare if <50 yrs)

  • Zostavax reduces risk in older adults


Management

  • First-line: Lignocaine 5% patch (localised pain)

  • Systemic first-line: Amitriptyline 10 mg nocte, titrate as needed

  • Second-line: Pregabalin 75 mg OD or Gabapentin 100 mg BD (adjust per response)

  • Adjuvants: Paracetamol, ice massage, Duloxetine if needed

  • Refractory cases: TENS (2 weeks), Tramadol 100 mg daily, opioids

  • CBT for chronic pain & mood disturbances

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Vaccination Against Shingles & PHN

  • Recommended ≥60 yrs (funded 70–79 yrs)

  • Household contacts ≥50 yrs (if living with immunocompromised patients)

  • Give before an outbreak, NOT during active shingles

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Contraindications

  • Pregnancy or ≤4 weeks postpartum

  • Shingles within past year (temporary immunity)

  • Immunocompromised (live vaccine risk)

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Notes

  • Antiepileptics & topical steroids ineffective for shingles/PHN

  • Same management principles apply to Ramsay Hunt syndrome

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